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Harmaline - 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole - Harmala Alkaloid Beta-carbolide.

Harmaline is the RIMA (Reversible Inhibitor of Monoamineoxidase-A) and acts as a short term MAOI (MonoAmineOxidase Inhibitor).

It is an unscheduled drug (perfectly legal) and is found abundantly in Syrian Rue seeds.

Next semester I plan to expand my experiments to include the extraction and experimentation with this drug, but of most interest is the drug interactions that Harmaline has. Since MAO-A (MonoAmineOxidase type-A) is responsible for the breakdown on many neurotransmitters and neurotransmitter analogues (like norepinephrine, dopamine, epinephrine, and serotonin) primarily through deamination. MAO-A is also deaminates many other chemicals that contain an amine group like Tyramine (found in food), the Phenylethylamine family (including Amphetamine, Methamphetamine, Dimethylamphetamine, Mescaline, Methylenedioxymethamphetamine (MDMA) etc.), the Tryptamine family (including Dimethyltryptamine, Psilocin, LSx (including ergine, isoergine, LSD, etc.), 

Since Harmaline is a MAOI and as-such inhibits the breakdown of such chemicals, it causes interesting interactions and changes the bioavailability of many chemicals. In some situations, this interaction is bad. Take for example, mixing an MAOI with Amphetamine (Adderall by prescription). Levels of aminated Amphetamine levels are much higher and as such creates a strong “speed” effect that easily crosses the threshold into an uncontrollable overdose which may lead to Amphetamine psychosis, hypertensive crises, or cardiac arrest. And let me tell you, as someone who has had a bad experience with a higher dosage of Amphetamine, it is not an enjoyable experience. However, if you were to combine Harmaline with N,N-Dimethyltryptamine (DMT), a drug which is normally inert when ingested orally due to MAO deamination, you get a interaction such that the DMT becomes orally active. This is how the shamanic sacrament Ayahuasca is made to be precise. It is a concoction made from a DMT-bearing plant and a Harmaline-bearing plant. This has led to the birth of modern Pharmahausca which is a calculated mixture of pure DMT and pure Harmaline as such to get the desired entheogenic effect.

I’m interested in expanding on Shulgin’s research in TiKAL (Tryptamines I Have Known And Loved) and seeing if I can explore the possibilities that can be gained by combining Harmaline with other psychoactive chemicals in specific, calculated ways.

Harmaline is the ideal MAOI for this task because it is a RIMA, which means that it carries the minimal risk of dietary interaction due to that fact that tyramine displaces Harmaline from MAO-A, allowing for the body to process tyramine normally (unless a large amount of harmaline was consumed) and prevent the risk of hypertensive or adrenic crisis.

However, due to the way that Harmaline reacts with most drugs, whenever an experiment is done with the drug Harmaline, an exactly amount of care must be taken. I have to watch what I eat, I am not allowed to take any aminated psychoactive drugs (including caffeine) except in special circumstances where I’m trying to learn about cross-interaction, especially drugs that modulate neurotransmitters, since Harmaline interferes with the metabolism of neurotransmitters and can easily lead to hypertensive crisis or serotonin syndrome when combined with most any stimulant or antidepressant. I also plan to avoid dietary supplements of all kinds to minimize risk.

To minimize risk, I also plan to titrate my experiments, starting with low dosages of Harmaline and scale up based on experiences and research. I am not planning to take any chances or put myself into any danger. I refuse to let this experiment end out like my last experiment where I modified my body pH to change the bioavailability of Amphetamine, and inadvertently put myself in a situation that was analogous to an Amphetamine overdose.

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